|
KMID : 0616120070380020108
|
|
Korean Journal of Pharmacognosy
2007 Volume.38 No. 2 p.108 ~ p.112
|
|
|
(Inhibitory Activity of the Fruit Extract of Gardenia jasminoides on Monoamine Oxidase)
|
|
Park Tae-Kyu
Hwang Keum-Hee
|
|
|
Abstract
|
|
|
|
We examined the inhibitory activities against monoamine oxidase (MAO) of Gardenia jasminoides in vitro and in vivo methods. Methanolic extract and ethylacetate fraction of Gardenia jasminoides fruit showed a significant inhibitory activity on MAO-A and MAO-B in vitro. The IC_{50} values of each fraction on MAO-A and MAO-B are as fo11owed; total methanol extracts 1.23 and 1.34 mg/ml, EtOAc fraction 0.72 and 0.77 mg/ml. Water-soluble fraction also showed IC_{50} values of 0.81 mg/ml on MAO-B. MAO-A activity was increased by the oral administration of ethanolic extract of G. jasminoides, while MAO-B activity was decreased. The concentration of serotonin of brain tissue administrated of ethanolic extract of G. jasminoides is slightly increased in rat. This tendency is not different from the activity of deprenyl which is a well known MAO inhibitor was used as a positive control. Consequently, we suggest that G. jasminoides may have the effects on the inhibitory activity against MAO This activity of G. jasminoides is considerable for development of functional materials for treatment and control of depression, dementia, Parkinson’’ disease, stress and promoting exercise, etc.
|
|
|
KEYWORD
|
|
|
Monoamine oxidase (MAO), Serotonin (5-HT), Gardenia jasminoides
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|